Molnupiravir

#GS3 #COVID-19 #HEALTH

A new drug called Molnupiravir has been shown to stop the transmission of SARS-CoV-2 in 24 hours. 

  • The antiviral drug Molnupiravir, or MK-4482/EIDD-2801, is taken orally
  • The research team repurposed MK-4482/EIDD-2801 against SARS-CoV-2 and tested it on ferrets.
  • In ferrets, the drug was shown to completely suppress transmission of SARS-CoV-2 in 24 hours. 
  • Researchers infected ferrets with SARS-CoV-2 and initiated treatment with MK-4482/EIDD-2801 when the animals started to shed the virus from the nose. 
  • Ferrets are a popular model for influenza and other respiratory infections because their lung physiology is similar to humans and researchers hope they will mimic aspects of Covid-19 in people such as its spread.
  • The drug basically stops replication of the copies of the virus’s RNA in the cell.
  • The drug is like any other anti-flu drug and was on our list of drugs to go into clinical trials. There are several promising drugs and they are under evaluation.
  • The phase 2/3 trial is a randomised, placebo-controlled double-blind clinical study to evaluate the efficacy and safety of MK-4482 in hospitalised adults with Covid 19 across 46 locations in various countries. 
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